The Opioid Analgesic Risk Evaluation Mitigation Strategies (REMS) was designed to ensure that the benefits of opioid analgesics used in the outpatient setting outweigh the risks (in patients whose clinicians have determined opioid analgesics to be an appropriate treatment option).
The FDA has required manufacturers of opioid analgesics to make education available for providers of these medications.
These manufactures have developed and are implementing this REMS through a consortium known as the REMS Program Companies (RPC).
RPC-supported REMS education is provided through accredited continuing education (CE) activities supported by independent educational grants from the RPC.
The FDA has developed an Opioid Analgesic REMS Education Blueprint for Health Care Providers Involved in the Treatment and Monitoring of Patients with Pain ("FDA Blueprint") on which the content of these accredited CE activities is based.
To date, the RPC has completed nine CE grant cycles - see the table below for a listing of grantees.
All accredited CE activities from the 2012-2021 CE Grant Cycles have been completed.
As of July 2024, there is a list of 68 ongoing RPC-supported REMS-compliant accredited CE activities. Please note that certain accredited CE provider grantees are still finalizing dates/locations for some of the activities.
Check back often as this listing is updated on a regular basis.
AKH Inc, Advancing Knowledge in Healthcare |
Managing Opioid Risk on the Front Lines: Focusing on Providers Who Care for Active Military Service Members and Veterans |
Trustees of Boston University |
Safer/Competent Opioid Prescribing Education - SCOPE of Pain: Educating the Healthcare Team |
California Academy of Family Physicians |
Collaborative Solutions: Uniting Clinicians to Address the Challenges of Chronic Pain and Opioid Use Disorder |
Pri-Med Institute, LLC |
P.A.C.T. Update: Practical Approaches to Comprehensive Treatment of Pain 2024-2025 |
National Comprehensive Cancer Network |
UNRAVELING CANCER PAIN DYNAMICS A Project ECHO Series and Adaptive Learning Activity |
American College of Osteopathic Family Physicians |
De-stress Pain Management: Rethinking Opioid and Nonopioid Therapies |
American Society of Health-System Pharmacists |
Opioid REMS Education: A Guide for the Interprofessional Team in Achieving Comprehensive Pain Management |
CME Outfitters, LLC |
Revolutionizing Pain Care: Applying The Latest Updates in Opioid REMS Education to Your Practice |
Medscape, LLC |
A Blueprint for Success in the Safe and Appropriate Prescribing of Opioid Analgesics |
Med Learning Group, LLC |
Key Updates in Fundamentals of the Use of Opioids for Pain Management and Prevention, Identification, and Mitigation of Non-medical Use of Prescription Opioids: A REMS-Compliant Continuing Education Program |
Massachusetts Medical Society |
Pain Management and Opioids Adaptive Learning from NEJM Group |
California Academy of Family Physicians |
The Power of Trust: Clinician associations helping providers address the public health challenges of chronic pain and opioid use disorder |
American Society of Anesthesiologists |
2023 Principles for Good Perioperative Pain Management |
Trustees of Boston University |
Safer/Competent Opioid Prescribing Education - SCOPE of Pain: Educating the Healthcare Team |
Purdue University |
Opioid Analgesics REMS: Paving the Way for Safe and Effective Solutions |
Howard University |
Addressing Racial Disparities in Pain Management and Opioid Analgesia: The Role of the Pharmacist in Improving Best Practice |
Pri-Med Institute, LLC |
P.A.C.T.: Practical Approaches to Comprehensive Treatment of Pain |
Massachusetts Medical Society |
NEJM Knowledge+ Pain Management and Opioids |
Cleveland Clinic |
The Role of Behavioral Medicine in Reducing Opioid Use |
Clinical Care Options |
Applying Best Practices in Pain Management: Delivering Holistic Patient-Centered Care to Minimize Health Disparities and Adverse Opioid Outcomes |
CME Outfitters, LLC |
Finding Balance: Optimizing the Treatment of Patients |
American College of Osteopathic Family Physicians |
Evidence-Based Strategies to Mitigate Opioid Prescribing for Pain Management: Navigating Alternatives and Emphasizing Safety |
Evolve Medical Education, LLC |
The Basics of Pain Management for Cancer Patients: From Diagnosis to Palliative Care |
Talem Health, LLC |
Tackling the Opioid Crisis in South Carolina: Strategies to Improve Best Practices and Patient Outcomes |
Trustees of Boston University |
Safer/Competent Opioid Prescribing Education - SCOPE of Pain: Educating the Healthcare Team |
University of Illinois |
Using Academic Detailing to improve appropriate use and monitoring of opioids |
American Society of Health-Systems Pharmacists |
Safely Managing our Patients’ Pain: An Opioid Analgesic REMS-compliant Accredited CE Initiative for Pharmacists |
California Academy of Family Physicians |
CO*RE |
Pri-Med Institute, LLC (d.b.a pmiCME) |
Strategies for Effective Pain Management in Clinical Practice |
Massachusetts Medical Society |
NEJM Knowledge+ Pain Management and Opioids |
Postgraduate Institute for Medicine |
Tackling the Opioid Crisis in Kentucky: Strategies to Improve Best Practices and Patient Outcomes |
UKHC CECentral |
Functional Pain and Opioids Clinically Useful Strategies (FOCUS) on Pain Management |
Clinical Care Options, LLC |
Opioid REMS Patient-Centered Pain Management: An Expert's Guide to Safe, Effective,and Appropriate Care for Patients with Pain |
American Society of Hematology |
Effective Management of Pain Along the Treatment of Hematologic MalignancY (EMPATHY) |
CME Outfitters, LLC |
Translating Data to Practice to Optimize the Lives of Patients with Pain |
Medicus Consultants in Education, Inc |
Delivering Results Through Small Groups: Using Completion of a REMS-Compliant Curriculum to Effect Change in Culturally Diverse Populations |
Trustees of Boston University |
Safer/Competent Opioid Prescribing Education - SCOPE of Pain: Educating the Healthcare Team |
Pri-Med Institute, LLC (d.b.a. pmiCME) |
Strategies for Effective Pain Management in Clinical Practice |
Purdue University |
Opioid REMS: Moving Forward, Safely and Effectively |
Massachusetts Medical Society |
NEJM Knowledge+ Pain Management and Opioids |
Postgraduate Healthcare Education, LLC |
Opioid Education: Special Populations Based on Age, Occupation, Sex, or Behaviors |
Postgraduate Institute for Medicine |
Tackling the Opioid Crisis in West Virginia: Strategies to Improve Best Practices and Patient Outcomes |
UKHC CECentral |
PEDIATRIC- Pain Evaluation During Infancy thru Adolescence: Treatment Impact and Considerations |
Clinical Care Options, LLC |
Expert Guidance for Effective Management and Appropriate Monitoring of Patients with Pain |
American Society of Anesthesiologists |
Pain Management Considerations For the Anesthesiologist By the Anesthesiologist |
Medicus Consultants in Education, Inc |
It Takes a Group: Opioid Analgesic REMS Initiative |
CME Outfitters, LLC |
OA 110121: On Point with Pain Management: Leveraging Change for Positive Outcomes |
Antidote Education Company |
FIRST DO NO HARM: STRATEGIES FOR MANAGING NON-CANCER PAIN IN YOUR CLINIC |
UMA Education, Inc. dba Global Education Group |
MANAGING OPIOID RISK IN ACUTE AND CHRONIC PAIN |
American Society of Health System Pharmacists |
Protecting Our Patients: An Opioid Analgesic REMS-compliant Accredited CE Initiative for Pharmacists |
Trustees of Boston University |
Safer/Competent Opioid Prescribing Education – SCOPE of Pain Educating the Healthcare Team |
Massachusetts Medical Society |
NEJM Knowledge+ Pain Management and Opioids, with additional learning resources |
AKH Inc., Advancing Knowledge in Healthcare |
Managing Opioid Risk on the Front Lines: Focus on Active Military Service Members and Veterans |
USF Health Professions Conferencing Corporation |
Evidence-based Pain Management: Addressing the Growing Role of Nurse Practitioners and Physician Assistants in Managing Patients with Acute and Chronic Pain |
Pri-Med Institute |
Strategies for Effective Pain Management |
CME Outfitters |
Heeding the Call for Safe and Responsible Pain Management in Our Communities |
Howard University |
Howard University Second Opioid Symposium and Naloxone Administration Training for Pharmacy Professionals |
Horizon CME |
Avoiding Risks While Managing Pain: Following the REMS Blueprint for Pain Management |
Medicus Consultants in Education |
It Takes a Group: Utilizing a Group-Based Model to Drive Completion of a REMS-Compliant Curriculum at Jefferson Health and Hackensack Meridian Health |
Postgraduate Healthcare Education |
Building Pharmacist Skills in Opioid Analgesic Therapy: The Power-Pak C.E. Opioid Analgesic Therapy Certificate Program for Pharmacists |
University of Kentucky |
Pain COACH: Pain Assessment Interventions Needed when Considering Older Adult Care for Healthcare providers |
Primary Provider |
Title |
Trustees of Boston University |
Safe and Competent Opioid Prescribing Education – SCOPE of Pain Educating the Healthcare Team |
Johns Hopkins University |
Get SMART 'Mobile'- Safe Means of Administering the Right Therapy |
MediCom Worldwide, Inc. |
Safe and Effective Prescribing of Opioid Analgesics: A Hands-on Case-based Clinical Curriculum |
Postgraduate Institute for Medicine |
Get SMART – Safe Means of Administering the Right Therapy (Get SMART Nationals) |
Postgraduate Institute for Medicine |
Talem ACO Summit Series: Safe and Appropriate Opioid Prescribing: A Systems-based Approach |
American Society of Anesthesiologists |
ASA Pain: Anesthesiologists Tailored Approach to Patient Safety Considerations When Using Opioid Analgesics |
University of North Texas Health Science Center |
Opioid Analgesic: Risk Evaluation and Mitigation Strategy (REMS) |
Antidote Education Company |
First Do No Harm: Safe and Effective Management of Chronic Pain |
CO*RE |
CO*RE's Pain Management and Opioids: Balancing Risks and Benefits |
University of Kentucky |
Get SMART – Safe Means of Administering the Right Therapy – University of Kentucky |
Howard University |
The "Eye" of the Opioid Analgesic Addiction Storm – A National Crisis and "REMS" Call to Action: The Essential, Ethical & Obligatory role of Pharmacists and Pharmacy Technicians to Teach, Treat and Educate Patients and Families |
USF Health Professions Conferencing Corporation |
RFA 090618: Opioid Analgesic: Risk Evaluation and Mitigation Strategy (REMS) |
Massachusetts Medical Society |
NEJM Knowledge+ Pain and Addiction Module |
Primary Provider |
Title |
Trustees of Boston University |
Safe and Competent Opioid Prescribing Education for Chronic Pain (SCOPE of Pain): Incorporating ER/LA Opioid Analgesics REMS into Practice |
Johns Hopkins University |
Get SMART 'Mobile'- Safe Means of Administering the Right Therapy (Get SMART Mobile) |
Postgraduate Institute for Medicine |
Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (Get SMART ER/LA Opioids) |
Pri-Med Institute |
SAFE Opioid Prescribing; Strategies, Assessment, Fundamentals, and Education |
CO*RE |
Opioid Prescribing Safe Practice, Changing Lives |
Global Education Group |
Extension Grant: Extended-Release and Long-Acting Opioid Analgesics: Risk Evaluation and Mitigation Strategy (REMS) |
Primary Provider |
Title |
Trustees of Boston University |
Safe and Competent Opioid Prescribing Education for Chronic Pain (SCOPE of Pain): Incorporating ER/LA Opioid Analgesics REMS into Practice |
Johns Hopkins University |
Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (Get SMART ER/LA Opioids) |
Postgraduate Institute for Medicine |
Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (Get SMART ER/LA Opioids) |
Pri-Med Institute |
SAFE Opioid Prescribing; Strategies, Assessment, Fundamentals and Education |
CO*RE |
CO*RE: Opioid Prescribing Safe Practice, Changing Lives |
Dannemiller, Inc. |
REMS Resource: Tools for Safe Opioid Prescribing in Chronic Pain Management |
Primary Provider |
Title |
Trustees of Boston University |
Safe and Competent Opioid Prescribing Education for Chronic Pain (SCOPE of Pain): Incorporating ER/LA Opioid Analgesics REMS into Practice |
Johns Hopkins University |
Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (Get SMART ER/LA Opioids) |
Florida Medical Association |
Opioid REMS: Achieving Prescriber Compliance and Patient Satisfaction |
Ultimate Medical Academy |
A Comprehensive Approach to the Safe Management of Extended-Release/Long-Acting Opioids |
American Academy of Physical Medicine and Rehabilitation |
Interactive Educational Arcade on Pain, including Prescriber Education for ER/LA |
Postgraduate Institute for Medicine |
Solutions for Safe ER/LA Opioid Prescribing in a New Era of Health Care Reform. A Multi-disciplinary REMS Initiative for a Changing Health Care Delivery Environment |
Postgraduate Institute for Medicine |
Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (Get SMART ER/LA Opioids) |
Pri-Med Institute |
SAFE Opioid Prescribing; Strategies, Assessment, Fundamentals and Education |
CO*RE |
CO*RE 2015: Achieving Safe Use While Improving Patient Care |
Primary Provider |
Title |
Trustees of Boston University |
Safe and Competent Opioid Prescribing Education for Chronic Pain (SCOPE of Pain): Incorporating ER/LA Opioid Analgesics REMS into Practice |
Pri-Med Institute, LLC |
Safe Opioid Prescribing Strategies. Assessment. Fundamentals. Education |
University of Washington |
Collaborative Opioid Prescribing Education (COPE) REMS Training Program |
CO*RE |
CO*RE 2015: Achieving Safe Use While Improving Patient Care |
Florida Medical Association |
Opioid REMS: Achieving Prescriber Compliance and Patient Satisfaction |
Postgraduate Institute for Medicine |
PCE Pain Workshop Series - Safe Means of Administering the Right Therapy - Extended-Release and Long-Acting Opioids (SMART ER/LA OPIOIDS) |
Dannemiller, Inc. |
REMS Resource: Tools for Safe Opioid Prescribing in Chronic Pain Management |
Primary Provider |
Title |
University of Washington School of Medicine |
Collaborative Opioid Prescribing Education (COPE) REMS Training Program |
Temple University School of Medicine |
INSIDE Chronic Pain Management: INspiring System Improvement With Data-Driven Education |
Montefiore/Albert Einstein College of Medicine |
PainEDU REMS Education Program |
American Academy of Pain Management |
The Emerging Solutions in Pain Responsible Opioid Prescribing Initiative |
University of Cincinnati College of Medicine |
A Comprehensive Curriculum to Address "Extended-Release and Long-Acting Opioid Analgesics REMS" |
University of Nebraska Medical Center |
Responsible Opioid Prescribing: A Live and Enduring Educational Program |
University of North Texas Health Science Center/Texas College of Osteopathic Medicine Foundation |
Effective Strategies for Chronic Pain Management: A Risk Evaluation and Mitigation Strategy for ER/LA Opioid Analgesics |
Primary Provider |
Title |
Trustees of Boston University |
SCOPE of Pain: Safe and Competent Opioid Prescribing Education |
CO*RE |
CO*RE REMS Initiative: A Collaborative Solution to the ER/LA Opioid Public Health Crisis |
American College of Physicians |
SAFE Opioid Prescribing: Strategies. Assessment. Fundamentals. Education. |
Utah Medical Association Foundation |
Utah ER/LA Opioid Analgesics Risk Evaluation and Mitigation Strategy (REMS) Educational Programming Project |
Association for Hospital Medical Education |
AHME Collaborative for REMS Education |
For further information on the Opioid Analgesic REMS, please refer to the FDA website.
For further inquiries relating to educational grants for the Opioid Analgesic REMS, please refer to the Frequently Asked Questions regarding Continuing Education.